In the authors' words
“No significant main effects of the diet-and-exercise program and of glucosamine sulfate were found on incident knee osteoarthritis.”
What was measured
- Joint pain No difference found
About the study
- Type
- Randomised trial
- Who took part
- Midlife women, overweight or obesity, osteoarthritis or joint pain
- How many
- 407
- How long
- 130 weeks
- Exercise
- Exercise with diet
- Cited
- 65 times, per Europe PMC
- PubMed ID
- 25818496
How to read this. Each line is one study, summarised in plain language from its PubMed abstract, with the authors' own sentence underneath on the study page. A count of studies is not a verdict: trials differ in size, length and quality, and a result in one group of women may not hold in another. Nothing here is medical advice.
Summaries are generated, then checked by machine against the abstract they came from; any summary that could not be matched word for word was left out. Our clinical lead is reviewing the summaries topic by topic, and this note will change when that is done. Corpus last refreshed 2026-11-03. Spotted a mistake? Tell us and we will fix the summary or remove the study.
Similar studies
- Breast cancer survivors did a 12-month remote diet and physical activity weight loss program and reported greater reductions in weight, fat mass, waist size, glucose and musculoskeletal pain than usual care.
- In 407 overweight women aged 50 to 60 followed 2.5 years, a diet and exercise program did not reduce the risk of developing knee osteoarthritis, unlike glucosamine sulfate.
- In 347 overweight women followed 2.5 years, a diet and exercise program reduced progression of meniscal extrusion on knee MRI but not other osteoarthritis features, compared with placebo.
- Perimenopausal women received education, diet guidance, or diet plus resistance exercise for 3 months; all groups reduced climacteric symptom scores, with the combined group showing broad symptom improvement.