In the authors' words
“Participants who maintained weight loss at 30 months had statistically significantly greater decreases in free estradiol and free testosterone (Ptrend = 0.02 and Ptrend = 0.04, respectively) and increases in SHBG (Ptrend < 0.0001) versus those who did not have sustained weight loss.”
What was measured
- Hormone levels Mixed results
About the study
- Type
- Randomised trial
- Who took part
- Postmenopausal, overweight or obesity
- How many
- 439
- How long
- 78 weeks
- Exercise
- Exercise with diet
- Cited
- 22 times, per Europe PMC
- PubMed ID
- 30461557
How to read this. Each line is one study, summarised in plain language from its PubMed abstract, with the authors' own sentence underneath on the study page. A count of studies is not a verdict: trials differ in size, length and quality, and a result in one group of women may not hold in another. Nothing here is medical advice.
Summaries are generated, then checked by machine against the abstract they came from; any summary that could not be matched word for word was left out. Our clinical lead is reviewing the summaries topic by topic, and this note will change when that is done. Corpus last refreshed 2026-11-03. Spotted a mistake? Tell us and we will fix the summary or remove the study.
Similar studies
- A meta-analysis of six RCTs in inactive postmenopausal women found combined exercise and reduced calorie diet, lasting 16 to 52 weeks, lowered estrogen and testosterone levels more than exercise alone.
- Over 12 months, overweight postmenopausal women assigned to diet, exercise, or both reported lower estrogen and testosterone levels, with the largest effects in combined diet plus exercise.
- A review of 43 studies found diet and exercise interventions, especially combined with weight loss, better controlled estrogen levels linked to breast cancer risk in postmenopausal women.
- Overweight postmenopausal women did 12 months of diet, aerobic exercise, or both; diet and diet plus exercise raised adiponectin and lowered leptin, exercise alone had smaller effects.